Intestinal Polyposis associated with Pigmentation of Oral Mucosa

Oral Pigmentation and Intestinal Polyposis

IN 1921 Peutz described a family with intestinal polyposis and spots of melanin pigmentation in and around the mouth. Prior to this, in 1896, Sir Jonathan Hutchinson described two girls with pigmented patches in the oral mucosa and around the mouth. Later, Parkes Weber (1919) reported that one of these twins died of what appeared to be an intussusception. Since 1921 over one hundred cases have ...

Intestinal polyposis associated with melanosis oris.

Weber (1919) described a case of acute intussusception in one of a pair of twins originally noticed by Hutchinson (1896) to have oral pigmentation. Peutz (1921) recorded a family of seven, and Jeghers, McKusick and Katz (1949) reported 10 cases of melanosis of the lips and buccal mucosa together with polyposis of the gastro-intestinal tract. The latter's report included a review of the literatu...

Differentiated thyroid cancer associated with intestinal polyposis syndromes: a review.

Intestinal polyposis syndromes, such as familial adenomatous polyposis (FAP) and Cowden's syndrome, are often associated with extraintestinal manifestations, and while many of these manifestations are benign, malignant extraintestinal manifestations, such as differentiated thyroid cancers, do occur. Although differentiated thyroid cancers (ie, papillary and follicular thyroid carcinomas) are as...

Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance.

Intestinal Polyposis